Good news for coffee drinkers - caffeine protects the brain!
protects the active ingredient in coffee contained caffeine stimulating the brain from the effects of a high fat diet and probably to some degree against Alzheimer's. This surprising conclusion scientists draw at least from recent animal studies with rabbits.
A group of pharmacologists from the University of North Dakota, headed by Prof. Jonathan D. Geiger studied at a "rabbit model," the consequences of a high fat diet with high cholesterol content has on the brain of the animals. Cholesterol and saturated but also unsaturated (essential) fatty acids lead to excessive damage to the tiny cell membranes, which then triggers a nonspecific immune response. There is a weak inflammation, which leads to the demise of affected brain cells. The rabbits were divided into four groups. Two groups received the fat-rich diet, but one of them was additionally 3mg caffeine mixed into the drinking water.
Allegiance Source: http://www.animal-spirit.at/
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corresponds transmitted to humans only a single cup of coffee per day! Another two groups received normal diet, one with and one without additional caffeine. After twelve weeks had a high-fat diet with plenty of cholesterol, the brains of animals that caffeine was also mixed into the drinking water, have suffered less damage than the brains of animals that had received no caffeine. In the control group, there were no differences between the groups with and without caffeine. Brain damage, there was obviously no.
A coffee a day is enough already!
Source: http://its-coffeetime.de/
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were each examined the olfactory bulb, but also parts of the cortex (perceptual processing, motor skills and higher mental functions) and the hippocampus (Gedächnisbildung, transfer of Gedächnisinhalten from the short-term to the Langzeitgedächnis). It can be damaged or dead brain cells, but also antibodies and signal substances readily detected as a result of inflammation. AStudienleiter Jonathan Geiger is convinced that caffeine protects the human brain from the adverse effects of a high-fat diet and suggested a vorbeugnde effect of caffeine against Alzheimer's. http://www.medizininfo.de
were each examined the olfactory bulb, but also parts of the cortex (perceptual processing, motor skills and higher mental functions) and the hippocampus (Gedächnisbildung, transfer of Gedächnisinhalten from the short-term to the Langzeitgedächnis). It can be damaged or dead brain cells, but also antibodies and signal substances readily detected as a result of inflammation. AStudienleiter Jonathan Geiger is convinced that caffeine protects the human brain from the adverse effects of a high-fat diet and suggested a vorbeugnde effect of caffeine against Alzheimer's. http://www.medizininfo.de
cholesterol metabolism source!
damage, a high blood cholesterol in the blood-brain barrier that normally prevents penetration of harmful substances from the blood into the brain. The brain is supplied by a network of fine blood vessels. Through these blood vessels such as the brain with nutrients and oxygen is supplied. The walls of these blood vessels form in its entirety, the blood-brain barrier. Critical to the functioning of the blood-brain barrier, so-called tight-junction proteins (= tight junction tight connection) that will help the blood vessel walls of the brain for a particularly high degree of sealing. The membrane proteins, they "rivet" the cell membranes adjacent epithelial cells, allowing a diffusion barrier to control the mass transfer. Epithelial cells (surface cells) cover, similar to roof tiles, as single-or multi-cell layers, the inner and outer body surfaces. Lose the tight-junction proteins, its cohesion, it will no longer prevent the blood-brain barrier more permeable and the penetration of pollutants effectively. A leaky blood-brain barrier probably favors the development of Alzheimer's dementia, Parkinson's and other neurodegenerative diseases, ie diseases that are associated with a progressive loss of nerve cells. Caffeine can counteract the loss of memory, had already Earlier studies in humans and animals have shown. The exact mechanism of action of caffeine was now, however, unclear. Geiger and his colleagues now believe to have understood it the first time: The caffeine promotes the biosynthesis of tight-junction proteins and thus protects the blood-brain barrier such as the adverse effects of cholesterol. This prevents the penetration of pollutants into the brain. The effects of caffeine in the brain will go after the working group to Geigerl continue to find new therapies for neurodegenerative diseases. is a first approach it all: caffeine apparently blocks especially adenosine receptors. Adenosine is a small molecule that both as a building block of nucleic acids (DNA, RNA) and adenosine triphosphate (ATP) is used, on the other hand, it regulates the function of virtually every body cell. The DNA (deoxyribonucleic acid) stores genetic information, RNA (ribonucleic acid) is in the transfer and implementation of information involved with protein biosynthesis. DNA and RNA are predominantly located in the nucleus (nucleus lat core), hence the name. The building blocks of nucleic acids, nucleotides, each composed of a phosphoric acid, a sugar and one base. These building blocks combine to form long strands of DNA into a double strand, the famous double helix, the RNA only a single strand. ATP is the universal energy carrier the cell. The energy can be released by fragmentation of the molecule and then drives all enrgieverbrauchenden processes in the cell.
damage, a high blood cholesterol in the blood-brain barrier that normally prevents penetration of harmful substances from the blood into the brain. The brain is supplied by a network of fine blood vessels. Through these blood vessels such as the brain with nutrients and oxygen is supplied. The walls of these blood vessels form in its entirety, the blood-brain barrier. Critical to the functioning of the blood-brain barrier, so-called tight-junction proteins (= tight junction tight connection) that will help the blood vessel walls of the brain for a particularly high degree of sealing. The membrane proteins, they "rivet" the cell membranes adjacent epithelial cells, allowing a diffusion barrier to control the mass transfer. Epithelial cells (surface cells) cover, similar to roof tiles, as single-or multi-cell layers, the inner and outer body surfaces. Lose the tight-junction proteins, its cohesion, it will no longer prevent the blood-brain barrier more permeable and the penetration of pollutants effectively. A leaky blood-brain barrier probably favors the development of Alzheimer's dementia, Parkinson's and other neurodegenerative diseases, ie diseases that are associated with a progressive loss of nerve cells. Caffeine can counteract the loss of memory, had already Earlier studies in humans and animals have shown. The exact mechanism of action of caffeine was now, however, unclear. Geiger and his colleagues now believe to have understood it the first time: The caffeine promotes the biosynthesis of tight-junction proteins and thus protects the blood-brain barrier such as the adverse effects of cholesterol. This prevents the penetration of pollutants into the brain. The effects of caffeine in the brain will go after the working group to Geigerl continue to find new therapies for neurodegenerative diseases. is a first approach it all: caffeine apparently blocks especially adenosine receptors. Adenosine is a small molecule that both as a building block of nucleic acids (DNA, RNA) and adenosine triphosphate (ATP) is used, on the other hand, it regulates the function of virtually every body cell. The DNA (deoxyribonucleic acid) stores genetic information, RNA (ribonucleic acid) is in the transfer and implementation of information involved with protein biosynthesis. DNA and RNA are predominantly located in the nucleus (nucleus lat core), hence the name. The building blocks of nucleic acids, nucleotides, each composed of a phosphoric acid, a sugar and one base. These building blocks combine to form long strands of DNA into a double strand, the famous double helix, the RNA only a single strand. ATP is the universal energy carrier the cell. The energy can be released by fragmentation of the molecule and then drives all enrgieverbrauchenden processes in the cell.
The role of nucleic acids (DNA, RNA) and the adenosine triphosphate (ATP) ...
Links: through replication, the genetic material is duplicated before cell division.
When transcribing the genetic information from DNA to RNA moving is being rewritten. In the translation the genetic information is converted by protein synthesis.
Right: by "cold combustion" of nutrients is stored energy in the form of winner and Adenosintriphoshat (ATP). By splitting this energy carrier molecule in adenosine diphosphate (ADP) and phosphoric acid (P), the energy is released again, and then drives numerous energy-consuming processes in the cell. Thereafter, the ATP is regenerated.
at all HEREIN enzymes in response promoters (catalysts) are involved.
Source: Wikipedia and http://www.brooklyn.cuny.edu/bc/ahp/LAD/C7/C7_atp.html
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The regulatory properties of adenosine are mediated by receptors. There are four varieties, which have different tissue distribution. Adenosine receptors are stimulated when cells have high energy needs and consumes a lot of ATP, and adenosine is released. The adenosine signal acts as a "speed limit" of cellular metabolism. A repeal of this "speed limit" increases in brain cells and their activity is achieved through the enjoyment of coffee or tea. Caffeine displaces adenosine from its receptors, thereby raising its effect on (antagonistic effect). The occupation of adenosine receptors with caffeine is in derogation of that is the "speed limit" of brain cells by adenosine. Hence the well-known and respected, encouraging effect caffeine-containing beverages. Of course, in this way are also biosynthetic (eg from Tigh-junction proteins) of the cells stimulated.
Jens Christian Heuer
